AP3-R
A triple-agonist research peptide targeting GIP, GLP-1, and glucagon receptors. Available in 15mg, 20mg, and 30mg lyophilized vials, third-party tested at 98%+ purity.
What Is AP3-R?
AP3-R is research-grade retatrutide — a novel triple-agonist peptide that activates three distinct receptors: glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon. This tri-receptor mechanism distinguishes it from single and dual-agonist compounds currently under investigation. In Phase 2 clinical trials published in The New England Journal of Medicine, retatrutide demonstrated significant effects on metabolic parameters including body weight, glucose regulation, and lipid profiles.
History
Retatrutide was developed by Eli Lilly and Company and first entered clinical investigation in 2021. The compound emerged from research into multi-receptor agonism as an approach to metabolic disease, building on the success of dual-agonist compounds like tirzepatide. The Phase 2 trial results, published in 2023, generated significant interest in the research community due to the magnitude of metabolic effects observed with tri-receptor activation. Phase 3 trials are ongoing as of 2025.
For research purposes only. Not for human consumption.
Certificate of Analysis (COA)
Every batch of our peptides is independently tested by third-party laboratories to verify purity, identity, and potency. We maintain 98%+ purity standards across our entire product catalog.
Reconstitution & Storage
Reconstitute with bacteriostatic water (BAC water). Using a sterile syringe, slowly inject 1-2mL of BAC water into the vial, directing the stream against the glass wall. Do not inject directly onto the lyophilized powder. Gently swirl until fully dissolved. Do not shake.
Store unreconstituted vials at room temperature away from direct sunlight. After reconstitution, store at 2-8°C (standard refrigerator). Use within 30 days of reconstitution. Do not freeze.
For research purposes only.
Shipping & Handling
All orders ship within 1-2 business days via USPS Priority or UPS Ground. Peptides are shipped in insulated packaging to maintain product integrity during transit.
Free shipping on orders over $150. Standard shipping rates apply for orders under $150. Expedited shipping options available at checkout.
All packages are shipped discreetly with no external branding or product identifiers. Tracking information is provided via email once your order ships.
All products sold on this website are intended for research and identification purposes only and are not intended for human dosing, injections, or ingestion. These products are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for legitimate laboratory research and not for human or animal consumption.
AP3-R
Frequently Asked Questions
What does AP3-R (retatrutide) do?
AP3-R is Protocol Aminos' research-grade retatrutide — a triple-agonist peptide activating GIP, GLP-1, and glucagon receptors simultaneously. Published Phase 2 data in The New England Journal of Medicine documents significant effects on metabolic parameters including body weight, glucose regulation, and lipid profiles.
What is retatrutide?
Retatrutide is a novel triple-agonist peptide developed by Eli Lilly activating three receptors: GIP, GLP-1, and glucagon. This tri-receptor mechanism distinguishes it from dual-agonists like tirzepatide and single-target GLP-1 compounds.
Is AP3-R (retatrutide) safe?
Retatrutide has been evaluated in Phase 2 clinical trials published in NEJM and The Lancet. Phase 3 trials are ongoing as of 2025. Protocol Aminos sells AP3-R for research purposes only. These are research findings and do not constitute medical advice.
Where to buy retatrutide?
Protocol Aminos sells AP3-R (retatrutide) for laboratory research use only in 15mg, 20mg, and 30mg lyophilized vials, third-party tested at 98%+ purity with batch-specific COAs.
What is the difference between retatrutide and tirzepatide?
Retatrutide is a triple-agonist (GIP/GLP-1/glucagon); tirzepatide is a dual-agonist (GIP/GLP-1). The additional glucagon receptor activity is studied for effects on energy expenditure. Protocol Aminos carries both: AP3-R (retatrutide) and AP2-T (tirzepatide).
How much is AP3-R?
AP3-R is offered in 15mg ($210), 20mg, and 30mg ($235). All ship in lyophilized (freeze-dried) form with a batch-specific COA. Free shipping on orders over $150.
Do research peptides come with instructions?
Each order includes product documentation with storage requirements, reconstitution guidelines, and handling instructions. For research guidance, visit our blog at /blog.
What's the actual amount in each vial?
Each vial contains the labeled amount of retatrutide in lyophilized form. The exact quantity is verified via third-party testing and documented on the batch-specific Certificate of Analysis.
Are additional supplies needed?
Yes. AP3-R ships lyophilized (freeze-dried) and must be reconstituted with bacteriostatic water prior to use. Bacteriostatic water and syringes are not included and must be sourced separately from a verified research supplier.
How long does an AP3-R vial last?
Unreconstituted lyophilized AP3-R has a long shelf life when stored in a cool, dry place away from direct light. Once reconstituted, store refrigerated at 2–8°C and use within the standard research window. Specific stability data is available on request.